4-methylmorpholine N-oxide in dichloromethane T=20°C; 18 h;

in hexane; dimethyl sulfoxide T=60°C; 0.0833333 h;

1: hydrogenchloride / dichloromethane; water; acetonitrile / 1 h / 20 °C 2: pyridine / dichloromethane / 12 h / 20 °C / Inert atmosphere 3: immobilized Candida antarctica lipase A; (+/-)-1-Aminoindan / diethyl ether / 2 h / 30 °C / Enzymatic reaction View Scheme

hydrogenchloride; acetic acid; tin(ll) chloride Heating;