N,N-双(2-羟乙基)乙二胺合成路线 （共 12 条）
反应条件
1: With C46H178O41Si42; titanium (IV) isopropoxide in toluene T=60°C; 24 h; Inert atmosphere; 2: With water; sodium hydroxide in toluene T=20°C; 4 h; Inert atmosphere;
参考文献
Laval, Stephane; Dayoub, Wissam; Pehlivan, Leyla; Metay, Estelle; Favre-Reguillon, Alain; Delbrayelle, Dominique; Mignani, Gerard; Lemaire, Marc
Tetrahedron, 2014 , vol. 70, # 4 p. 975 - 983
反应条件
ammonia; hydrogen; Ni/Re (6.8wtpercent/1.8wtpercent) on silica/alumina (80/20) T=165°C; P=85781.4 - 99537.9 Torr; 4 h; Autoclave; Product distribution / selectivity;
参考文献
WO2010/42159 A1, ;
Page/Page column 30-31 ;
反应条件
ammonia; hydrogen; Ni/Re (6.8wtpercent/1.8wtpercent) on silica/alumina (80/20) T=170°C; P=85781.4 - 99537.9 Torr; 10 h; Autoclave; Product distribution / selectivity;
参考文献
WO2010/42159 A1, ;
Page/Page column 30-31 ;
反应条件
hydrazine hydrate in methanol 2.5 h; Heating;
参考文献
Asseline, Ulysse; Chassignol, Marcel; Draus, Jolanta; Durand, Maurice; Maurizot, Jean-Claude
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 16 p. 3499 - 3511
反应条件
methanol und Erwaermen des Reaktionsprodukts mit wss.Salzsaeure;
参考文献
Journal of the American Chemical Society, , vol. 81, p. 3984,3986
参考文献
Gilead Sciences
Patent: US5414077 A1, 1995 ;
反应条件
1: phenol / 110 °C 2: thionyl chloride View Scheme
参考文献
Peck et al.
Journal of the American Chemical Society, 1959 , vol. 81, p. 3984,3986
反应条件
1: 5-(1,2-dithiolan-3-yl)pentanoic acid With 1,1'-carbonyldiimidazole in chloroform T=20°C; 1 h; Inert atmosphere; 2: 2-[N,N-bis(2-hydroxyethyl)amino]ethylamine in chloroform T=20°C; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 133, # 24 p. 9480 - 9496
反应条件
(i), (ii) /BRN= 1209228/, H2O; Multistep reaction;
参考文献
Price,C.C. et al.
Journal of Medicinal Chemistry, 1965 , vol. 8, p. 650 - 655
