(S)-(+)-2-甲基哌啶合成路线 （共 25 条）
反应条件
D-glucose; (S)-imine reductase from Streptomyces sp. GF3546; NADPH in aq. phosphate buffer; N,N-dimethyl-formamide T=30°C; pH=7; 18 h; Enzymatic reaction; Kinetics; enantioselective reaction;
参考文献
ChemCatChem, , vol. 5, # 12 p. 3505 - 3508
参考文献
Australian Journal of Chemistry, , vol. 61, # 7 p. 506 - 520
反应条件
hydrogen; nickel in toluene T=70°C; P=75.0075 Torr; 24 h; Autoclave;
参考文献
Parvulescu, Andrei N.; Jacobs, Pierre A.; De Vos, Dirk E.
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 1 p. 113 - 121
反应条件
triethylamine in tetrahydrofuran
参考文献
Tchabanenko, Kirill; Adlington, Robert M.; Cowley, Andrew R.; Baldwin, Jack E.
Organic Letters, 2005 , vol. 7, # 4 p. 585 - 588
Title/Abstract Full Text View citing articles Show Details
Tchabanenko, Kirill; Chesworth, Richard; Parker, Jeremy S.; Anand, Neel K.; Russell, Andrew T.; Adlington, Robert M.; Baldwin, Jack E.
Tetrahedron, 2005 , vol. 61, # 49 p. 11649 - 11656
反应条件
1.1: Et3N / tetrahydrofuran
2.1: 39 percent / RuO4; NaIO4 / ethyl acetate; H2O
3.1: 54 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 20 °C
4.1: 50 percent / LiCl; (i-Pr)2EtN / acetonitrile / 12 h
5.1: TFA / CH2Cl2 / 0 - 20 °C
5.2: NaCNBH3 / CH2Cl2; ethanol / 0.01 h / 20 °C
5.3: aq. NaHCO3 / CH2Cl2; ethanol / 20 °C
6.1: Et3N / CH2Cl2 / 14 h
7.1: 11 percent / H2 / PtO2 / ethanol / 12 h
8.1: 95 percent / TFA / CH2Cl2 / 1 h
9.1: 74 percent / sodium cyanoborohydride / acetonitrile; H2O / 1 h / 20 °C
View Scheme
参考文献
Tchabanenko, Kirill; Adlington, Robert M.; Cowley, Andrew R.; Baldwin, Jack E.
Organic Letters, 2005 , vol. 7, # 4 p. 585 - 588
