3-吡咯烷-1-甲酸苄酯合成路线 （共 23 条）
反应条件
1: 92 percent / Et3N / CH2Cl2; toluene / 10 h / 20 °C 2: 90 percent / Grubbs catalyst / CH2Cl2 / 6 h / 20 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 17, # 20 p. 2876 - 2883
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; Xtalfluor-E® in dichloromethane T=-78 - 20°C; 24 h; Inert atmosphere; optical yield given as percent ee;
参考文献
Journal of Organic Chemistry, , vol. 75, # 10 p. 3401 - 3411
反应条件
1: With borane in tetrahydrofuran T=0 - 20°C; 16 h; 2: With sodium hydroxide; water; dihydrogen peroxide in tetrahydrofuran T=0 - 20°C; 2.5 h; 3: With water; sodium hydrogensulfite in tetrahydrofuran 0.25 h;
参考文献
Actelion Pharmaceuticals Ltd.
Patent: US2009/247578 A1, 2009 ;
Location in patent: Page/Page column 14 ;
反应条件
1: mCPBA / CH2Cl2 / 0 - 20 °C 2: BD9884 / aq. phosphate buffer; acetonitrile / 22 °C / pH 7.5 View Scheme
参考文献
Zhao, Lishan; Han, Bin; Huang, Zilin; Miller, Mark; Huang, Hongjun; Malashock, Dan S.; Zhu, Zuolin; Milan, Aileen; Robertson, Dan E.; Weiner, David P.; Burk, Mark J.
Journal of the American Chemical Society, 2004 , vol. 126, # 36 p. 11156 - 11157
反应条件
1: With osmium(VIII) oxide; 4-methylmorpholine N-oxide in tetrahydrofuran; water; tert-butyl alcohol T=20°C; 16 h; 2: With hydrogen in methanol T=20°C; 16 h;
参考文献
NOVARTIS AG; FURET, Pascal; GROTZFELD, Robert Martin; JONES, Darryl Brynley; MANLEY, Paul; MARZINZIK, Andreas; PELLE, Xavier Francois Andre; SALEM, Bahaa; SCHOEPFER, Joseph; SPIESER, erich Alois
Patent: WO2013/171640 A1, 2013 ;
Location in patent: Paragraph 00720-00721 ;
参考文献
Brown, Herbert C.; Gupta, Ashok K.; Rangaishenvi, Milind V.; Vara Prasad, J. V. N.
Heterocycles, 1989 , vol. 28, # 1 p. 283 - 294
反应条件
1: With 1,1,1-trifluoropropanone; (ethylenedinitrilo)tetraacetic acid disodium salt in water; acetonitrile T=0°C; 0.166667 h; 2: With Potassium peroxomonosulfate; sodium hydrogencarbonate in water; acetonitrile T=0°C; pH=7; 2.16667 h;
参考文献
Pfizer Inc
Patent: US2005/256310 A1, 2005 ;
Location in patent: Page/Page column 12 ;
反应条件
in dichloromethane T=20°C; 18 h;
参考文献
NYCOMED GMBH; BARTELS, Bjoern; WEINBRENNER, Steffen; MARX, Degenhard; DIEFENBACH, Joerg; DUNKERN, Torsten; MENGE, Wiro M.P.B.; CHRISTIAANS, Johannes A. M.
Patent: WO2010/15588 A1, 2010 ;
Location in patent: Page/Page column 94 ;
WO 2010/015588 A1
反应条件
sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; (Ipc)2BH 1.) 0 deg C, 4 h; 2.) 25 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Brown, Herbert C.; Prasad, J. V. N. Vara
Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 2049 - 2054
参考文献
Brown, Herbert C.; Gupta, Ashok K.; Rangaishenvi, Milind V.; Vara Prasad, J. V. N.
Heterocycles, 1989 , vol. 28, # 1 p. 283 - 294
