1-(2-硝基苯基)-L-脯氨酸合成路线 (共 3 条)
反应条件
in methanol; palladium-carbon catalyst
参考文献
Wakamoto Pharmaceutical Co., Ltd.
Patent: US6225306 B1, 2001 ;
反应条件
1: glacial acetic acid, iron powder / 3 h / 60 - 65 °C
2: 80 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 18 h / Heating
View Scheme
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746
反应条件
1: glacial acetic acid, iron powder / 3 h / 60 - 65 °C
2: 80 percent / LiAlH4 / diethyl ether; tetrahydrofuran / 18 h / Heating
View Scheme
参考文献
Abou-Gharbia, Magid; Freed, Meier E.; McCaully, Ronald J.; Silver, Paul J.; Wendt, Robert L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1743 - 1746