4-溴-2-三氟甲基苯甲酸合成路线 （共 8 条）
反应条件
1: With 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid T=20°C; 15 h; 2: With sodium hydroxide; water pH=12; 3: With hydrogenchloride in water pH=1;
参考文献
EP1445253 A1, ;
Page 25 ;
EP 1445253 A1
反应条件
1: With sodium hydroxide; water in dimethyl sulfoxide T=100°C; 16 h; 2: With hydrogenchloride in water; dimethyl sulfoxide
参考文献
WO2006/21759 A1, ;
Page/Page column 41 ;
WO 2006/021759 A1
反应条件
1: 4-bromo-1-iodo-2-(trifluoromethyl)benzene With isopropylmagnesium chloride in tetrahydrofuran T=-20°C; 2 h; 2: carbon dioxide in tetrahydrofuran T=-20°C; 1 h; Further stages.;
参考文献
Hattori, Yoshihide; Yamamoto, Hitoshi; Ando, Hideya; Kondoh, Hirofumi; Asano, Tomoyuki; Kirihata, Mitsunori; Yamaguchi, Yoshihiro; Wakamiya, Tateaki
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 2198 - 2205
反应条件
1.1: KBr; NaBO3*4H2O; AcOH / (NH4)6Mo7O24*4H2O / 3 h / 20 °C 2.1: 2.73 g / I2; tert-butyl nitrite / acetonitrile / 16 h / 20 °C 3.1: i-propylmagnesium chloride / tetrahydrofuran / 2 h / -20 °C 3.2: 66.4 percent / tetrahydrofuran / 1 h / -20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 5 p. 2198 - 2205
参考文献
Journal of the American Chemical Society, , vol. 73, p. 3932
反应条件
1.1: 2.73 g / I2; tert-butyl nitrite / acetonitrile / 16 h / 20 °C 2.1: i-propylmagnesium chloride / tetrahydrofuran / 2 h / -20 °C 2.2: 66.4 percent / tetrahydrofuran / 1 h / -20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 15, # 5 p. 2198 - 2205
反应条件
potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct in N,N-dimethyl-formamide T=80°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28952 A1, 2012 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrogenchloride
Reflux;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: US2012/28952 A1, 2012 ;
Location in patent: Page/Page column 18-19 ;
