4-羟基-2-三氟甲基苯甲酸合成路线 (共 3 条)
反应条件
boron tribromide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dichloromethane
反应条件
sulfuric acid
Heating / reflux;
参考文献
WYETH; SIENA BIOTECH S.P.A.
Patent: WO2009/91832 A1, 2009 ;
Location in patent: Page/Page column 52 ;
反应条件
in methanol; hexanes; dichloromethane
1 h;
参考文献
Kim, Ronald M.; Parmee, Emma R.; Sinz, Christopher Joseph; Ziouzina, Olga A.
Patent: US2010/216764 A1, 2010 ;
Location in patent: Page/Page column 28 ;