2-氯-5-氨基三氟甲苯合成路线 （共 49 条）
参考文献
Geigy A. G.
Patent: US2745874 , 1954 ;
Full Text Show Details
Geigy A. G.
Patent: DE1003717 , 1954 ;
参考文献
Geigy A. G.
Patent: US2745874 , 1954 ;
Full Text Show Details
Geigy A. G.
Patent: DE1003717 , 1954 ;
反应条件
triethylamine in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 11 p. 2960 - 2967
参考文献
Justus Liebigs Annalen der Chemie, , vol. 562, p. 75,1114
反应条件
in benzene 12 h; Reflux; Product distribution / selectivity;
参考文献
US2012/53192 A1, ;
Page/Page column 4 ;
反应条件
(i) NaNO2, HCl, NaOAc, (ii) /BRN= 1697325/, CuSO4, Na2SO3, (iii) aq. HCl; Multistep reaction;
参考文献
DoAmaral,J.R. et al.
Journal of Medicinal Chemistry, 1971 , vol. 14, p. 862 - 866
反应条件
1: NaNO2; aqueous H2SO4 / anschliessendes Erwaermen mit wss. H2SO4 unter Einleiten von Wasserdampf View Scheme
参考文献
Mooradian et al.
Journal of the American Chemical Society, 1951 , vol. 73, p. 3470
反应条件
hydrogenchloride; tetrafluoroboric acid; sodium nitrite in water; ethyl acetate
参考文献
Fisons plc
Patent: US4607041 A1, 1986 ;
反应条件
sulfuric acid; sodium nitrite anschliessendes Erwaermen mit wss. H2SO4 unter Einleiten von Wasserdampf;
参考文献
Journal of the American Chemical Society, , vol. 73, p. 3470
US2489423 , ;
DE884196 , ;
DRP/DRBP Org.Chem.
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=110°C; 8 - 9 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2010/311980 A1, 2010 ;
Location in patent: Page/Page column 22-23 ;
