2-氯-5-氨基三氟甲苯合成路线 （共 49 条）
反应条件
1: 4-Chloro-3-(trifluoromethyl)benzenamine; 1,1'-carbonyldiimidazole in dichloromethane T=20°C; 16 h; Inert atmosphere; 2: 4-(4-aminophenoxy)pyridine-2-carboxylic acid methylamide in dichloromethane Inert atmosphere;
参考文献
Bankston, Donald; Dumas, Jacques; Natero, Reina; Riedl, Bernd; Monahan, Mary-Katherine; Sibley, Robert
Organic Process Research and Development, 2002 , vol. 6, # 6 p. 777 - 781
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide 24 h; Heating / reflux; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2010/311980 A1, 2010 ;
Location in patent: Page/Page column 22 ;
反应条件
1: pyridine / dichloromethane / 0 - 20 °C 2: pyridine / 3 h / 80 °C View Scheme
参考文献
Rawling, Tristan; McDonagh, Andrew M.; Tattam, Bruce; Murray, Michael
Tetrahedron, 2012 , vol. 68, # 30 p. 6065 - 6070
反应条件
in acetonitrile 24 h; Heating / reflux; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2010/311980 A1, 2010 ;
Location in patent: Page/Page column 22 ;
参考文献
US2003/144278 A1, ;
US 20030144278 A1
反应条件
1: 4-Chloro-3-(trifluoromethyl)benzenamine; 1,1'-carbonyldiimidazole in dichloromethane T=20°C; 16 h; 2: 4-(4-aminophenoxy)-2-pyridine-(N-(methyl-d3))carboxamide in dichloromethane T=20°C; 18 h;
参考文献
EP2548867 A1, ;
Paragraph 0075; 0076 ;
反应条件
1: 4-methyl-morpholine / chloroform / 25 h / 5 - 65 °C / |Reflux 2: dichloromethane; dimethyl sulfoxide / 0.17 h / 20 °C / |Inert atmosphere; |Large scale View Scheme
反应条件
acetic acid in water T=40 - 45°C; 1 - 2 h; Product distribution / selectivity;
参考文献
CIPLA LIMITED
Patent: US2010/311980 A1, 2010 ;
Location in patent: Page/Page column 21 ;
反应条件
pyridine in dichloromethane T=0 - 20°C; 2 h;
参考文献
MERCK PATENT GMBH
Patent: WO2004/19941 A1, 2004 ;
Location in patent: Page/Page column 156 ;
WO 2004/019941 A1
参考文献
The State of Oregon, acting by and through The Oregon State Board of Higher Education, acting for and on behalf of The Oregon Health Sciences University; The University of Oregon; The Regents of the University of California
Patent: US5514680 A1, 1996 ;
US 5514680 A
