2-硝基-4-三氟甲基苯甲酸合成路线 （共 14 条）
反应条件
nitric acid T=20°C; 2 h; Heating / reflux;
参考文献
Aventis Pharma Deutschland GmbH
Patent: US2005/124681 A1, 2005 ;
Location in patent: Page/Page column 16 ;
US 20050124681 A1
反应条件
hydrogen bromide Inert atmosphere;
参考文献
Suez, Gal; Bloch, Victoria; Nisnevich, Gennady; Gandelman, Mark
European Journal of Organic Chemistry, 2012 , # 11 p. 2118 - 2122
反应条件
nitric acid 1 h; Heating;
参考文献
Liebigs Annalen der Chemie, , # 6 p. 569 - 579
反应条件
thionyl chloride in tetrahydrofuran; chloroform
参考文献
Rohm and Haas Company
Patent: US4781750 A1, 1988 ;
反应条件
sodium hydroxide; palladium 10 on activated carbon in methanol T=20°C; P=9750.98 Torr;
参考文献
Gruenenthal GmbH
Patent: US2008/293749 A1, 2008 ;
Location in patent: Page/Page column 15 ;
反应条件
copper(I) oxide T=120°C; 24 h; Ionic liquid;
参考文献
Kessler, Michael T.; Gedig, Christian; Sahler, Sebastian; Wand, Patricia; Robke, Silas; Prechtl, Martin H. G.
Catalysis Science and Technology, 2013 , vol. 3, # 4 p. 992 - 1001
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=5250.53 Torr; 2 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/108591 A1, 2006 ;
Location in patent: Page/Page column 10; 66 ;
WO 2006/108591 A1
反应条件
4-methyl-morpholine; sodium tetrahydroborate; tert-butoxycarbonyl chloride in tetrahydrofuran T=-15°C; 0.0166667 h;
参考文献
Palanki, Moorthy S.S.; Erdman, Paul E.; Goldman, Mark E.; Suto, Carla; Suto, Mark J.
Medicinal Chemistry Research, 2000 , vol. 10, # 1 p. 19 - 29
反应条件
sulfuric acid T=20°C; 48 h; Heating / reflux;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/2342 A1, 2006 ;
Location in patent: Page/Page column 55 ;
反应条件
conc H2SO4 in methanol
参考文献
BAYER CORPORATION
Patent: US2004/102636 A1, 2004 ;
US 20040102636 A1
