2-硝基-4-三氟甲基苯甲酸合成路线 （共 14 条）
反应条件
in toluene T=80°C; 16 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/116412 A2, 2006 ;
Location in patent: Page/Page column 223; 224 ;
WO 2006/116412 A2
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane
T=20°C;
参考文献
Szczecinski, Przemyslaw; Gryff-Keller, Adam; Molchanov, Sergey
Journal of Organic Chemistry, 2006 , vol. 71, # 12 p. 4636 - 4641
反应条件
1: hydrazine / ethanol; H2O / Heating
View Scheme
参考文献
Li, Ming; Wen, Lirong; Wang, Xiao; Yao, Changsheng; Fu, Weijun; Zhao, Guilong; Hu, Fangzhong; Yang, Huazheng
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006 , vol. 45, # 2 p. 483 - 488
反应条件
1: palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C / 3800.26 Torr
2: 4 h / 160 - 180 °C / Inert atmosphere
3: phosphorus pentachloride; trichlorophosphate / 4 h / Reflux; Inert atmosphere
View Scheme
参考文献
Suez, Gal; Bloch, Victoria; Nisnevich, Gennady; Gandelman, Mark
European Journal of Organic Chemistry, 2012 , # 11 p. 2118 - 2122
