hydrogen fluoride T=130°C; Nickelgefaess;

sulfuric acid

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '27528911', constants.ctx, '0')">C₃₅H₂₀F₃₄NO₃^(1-)*Pd⁽²⁺⁾*Cl^(1-)</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605301', constants.ctx, '0')">N,N- diisopropylethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a> <br />T=140&deg;C;&nbsp;0.25&nbsp;h;&nbsp;&nbsp;Microwave irradiation;&nbsp;<br /> <br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '390339', constants.ctx, '0')">2-chloroformyl benzoic acid methyl ester</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '106420', constants.ctx, '0')">1-methyl-pyrrolidin-2-one</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />T=0&deg;C;&nbsp;0.5&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '508432', constants.ctx, '0')">4-chlorophenyl-magnesium bromide</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />T=-10 - 0&deg;C;&nbsp;4.25&nbsp;h;&nbsp;&nbsp;chemoselective reaction;&nbsp;<br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '1862501', constants.ctx, '0')">methyl 2-bromo-benzoate</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '4948473', constants.ctx, '0')">magnesium</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8127934', constants.ctx, '0')">lithium chloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '8128175', constants.ctx, '0')">zinc(II) chloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=0 - 25&deg;C;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br />Stage #2: <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '19239159', constants.ctx, '0')">CCl₂CuN^(2-)*2Li⁽¹⁺⁾</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />0.25&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br />Stage #3: <a href="#" onclick="return RXDsubstances(event, this, '471606', constants.ctx, '0')">4-chloro-benzoyl chloride</a> &nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />T=25&deg;C;&nbsp;2&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2037554', constants.ctx, '0')">sulfuric acid</a> <br /> <br /> &nbsp;

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