2-(间甲氧基苯基)环氧乙烷合成路线 （共 18 条）
反应条件
1: With N-bromosuccinmide; water; acetic acid in 1,4-dioxane T=0 - 20°C; 2: With sodium hydroxide in 1,4-dioxane; water T=20°C;
参考文献
METABOLIC SOLUTIONS DEVELOPMENT COMPANY LLC; COLCA, Gerard, R.; KLETZIEN, Rolf, F.
Patent: WO2014/93114 A1, 2014 ;
Location in patent: Paragraph 0391; 0392 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane T=50°C; 96 h;
参考文献
Alvarez; Granados; Lavilla; Salas
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 3 p. 745 - 750
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane
参考文献
Merck Frosst Canada, Inc.
Patent: US5104882 A1, 1992 ;
反应条件
sodium hydroxide in water; toluene
参考文献
Sanofi
Patent: US5130339 A1, 1992 ;
反应条件
potassium carbonate in acetone
参考文献
Haak, Robert M.; Berthiol, Florian; Jerphagnon, Thomas; Gayet, Arnaud J. A.; Tarabiono, Chiara; Postema, Christiaan P.; Ritleng, Vincent; Pfeffer, Michel; Janssen, Dick B.; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G.
Journal of the American Chemical Society, 2008 , vol. 130, # 41 p. 13508 - 13509
反应条件
1,4-dioxane; anhydrous sodium borate; water Reagens 4: wss. Schwefelsaeure; Erhitzen des Reaktionsprodukts mit wss. Kalilauge;
参考文献
Perrone, Roberto; Berardi, Francesco; Leopoldo, Marcello; Tortorella, Vincenzo; Lograno, Marcello D.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3045 - 3049
反应条件
potassium hydroxide in diethyl ether; water 0.5 h; Heating; Yield given;
参考文献
Perrone, Roberto; Berardi, Francesco; Leopoldo, Marcello; Tortorella, Vincenzo; Lograno, Marcello D.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3045 - 3049
反应条件
1: acetic acid; bromine 2: dioxane; sodium borate; water / Reagens 4: wss. Schwefelsaeure; Erhitzen des Reaktionsprodukts mit wss. Kalilauge View Scheme
参考文献
Fuchs
Journal of the American Chemical Society, 1956 , vol. 78, p. 5612
反应条件
in tetrahydrofuran; dimethyl sulfoxide 1) -5 to -10 deg C, 15 min; 2) 2 h, r.t.;
参考文献
Krug, Reinhard; Jugelt, Werner
Zeitschrift fuer Chemie (Stuttgart, Germany), 1981 , vol. 21, # 11 p. 406 - 407
反应条件
1: potassium carbonate / dioxane; H2O / Heating 2: 3-chloroperbenzoic acid; NaHCO3 / CH2Cl2; H2O / 2.5 h / 20 °C View Scheme
参考文献
Bernasconi, Silvana; Orsini, Fulvia; Sello, Guido; Di Gennaro, Patrizia
Tetrahedron Asymmetry, 2004 , vol. 15, # 10 p. 1603 - 1606
