1-苄基-4-甲基-1,2,3,6-四氢吡啶合成路线 （共 14 条）
反应条件
1: acetonitrile / 0.25 h / 85 °C / |Reflux 2: [{(η5-C5Me5)IrCl}2(μ-Cl)2]; potassium iodide; triethylammonium formate / dichloromethane / 24 h / 40 °C / |Sealed tube View Scheme
参考文献
Advanced Synthesis and Catalysis, , vol. 355, # 1 p. 35 - 40
反应条件
1.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.43 h / 5 - 10 °C / |Inert atmosphere; |Large scale 1.2: 17.3 h / 8 - 20 °C / |Inert atmosphere; |Large scale 1.3: |Large scale 2.1: sulfur trioxide pyridine complex; triethylamine / water / 1 h / 22 °C / |Inert atmosphere; |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 115 - 120
反应条件
in methanol; toluene
T=20 - 30°C; 12 h; Irradiation; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Silhankova, Alexandra; Davidova, Dagmar; Sputova, Michaela; Trska, Petr; Vaculikova, Dana; et al.
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 5 p. 1298 - 1304
反应条件
1: With 1-chloroethyl chlorocarbonate in dichloromethane
T=80°C;
2: With methanol
T=60°C; 6 h;
3: With hydrogenchloride in water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/126675 A1, 2009 ;
Location in patent: Page/Page column 132 ;
WO 2009/126675 A1
