2-(4-甲基哌嗪-1-基)噻唑-5-甲醛合成路线 （共 3 条）
反应条件
1: 1-methyl-4-thiazol-2-yl-piperazine With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - 0°C; Inert atmosphere; 2: (4-morpholinyl)methanone in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere;
参考文献
Tohoku University
Patent: EP2103611 A1, 2009 ;
Location in patent: Page/Page column 68-69 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20 - 90°C; 6 h;
参考文献
PIERRE FABRE MEDICAMENT; BEDJEGUELAL, Karim; RABOT, Remi; KALOUN, El Bachir; MAYER, Patrice; MARCHAND, Arnaud; RAHIER, Nicolas; SCHAMBEL, Philippe; BIENAYME, Hugues
Patent: WO2011/45344 A1, 2011 ;
Location in patent: Page/Page column 87 ;
WO 2011/045344 A1
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 140 °C 2.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 1.5 h / -78 - 0 °C / |Inert atmosphere 2.2: 1 h / -78 - -30 °C View Scheme
