(4-羟基苯甲酰基)乙酸甲酯合成路线 （共 7 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate T=20°C; 4 h;
参考文献
CONNEXIOS LIFE SCIENCES PVT. LTD.; RANGANATH RAO, Jagannath Madanahalli; ARUMUGAM, Nagarajan; ANSARI, Mohd Mudabbir; GUDLA, Chandrasekhar; PACHIYAPPAN, Shanmugam; RAMALINGAM, Manivannan; GEORGE, Jenson; ARUL, George Fernanda; BOMMEGOWDA, Y, Kenchegowda; ANGUPILLAI, Sathesh Kumar; KOTTAMALAI, Ramamoorthy; JIDUGU, Pradeep; RAO, D, Shivanageshwara
Patent: WO2012/11125 A1, 2012 ;
Location in patent: Page/Page column 194; 195-196 ;
WO 2012/011125 A1
反应条件
boron tribromide in dichloromethane T=0°C; 1 h;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 58 ;
US 20120277224 A1
反应条件
sodium hydride in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
CONNEXIOS LIFE SCIENCES PVT. LTD.; RANGANATH RAO, Jagannath Madanahalli; ARUMUGAM, Nagarajan; ANSARI, Mohd Mudabbir; GUDLA, Chandrasekhar; PACHIYAPPAN, Shanmugam; RAMALINGAM, Manivannan; GEORGE, Jenson; ARUL, George Fernanda; BOMMEGOWDA, Y, Kenchegowda; ANGUPILLAI, Sathesh Kumar; KOTTAMALAI, Ramamoorthy; JIDUGU, Pradeep; RAO, D, Shivanageshwara
Patent: WO2012/11125 A1, 2012 ;
Location in patent: Page/Page column 126-127 ;
WO 2012/011125 A1
反应条件
in N,N-dimethyl-formamide
反应条件
1.1: potassium carbonate / acetonitrile / 12 h / 20 °C 2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C 2.2: 12 h / -5 - 20 °C 3.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 4 h / 20 °C View Scheme
参考文献
WO2012/11125 A1, ;
WO 2012/011125 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / -5 °C 1.2: 12 h / -5 - 20 °C 2.1: hydrogen / palladium 10 on activated carbon / ethyl acetate / 4 h / 20 °C View Scheme
参考文献
WO2012/11125 A1, ;
WO 2012/011125 A1
反应条件
1: sodium hydride / 0.17 h / Reflux 2: boron tribromide / dichloromethane / 1 h / 0 °C View Scheme
参考文献
US2012/277224 A1, ;
US 20120277224 A1
