5-(三氟甲基)-1H-吲哚-3-乙胺合成路线 （共 7 条）
反应条件
1: With triphenylphosphine in methanol T=70°C; 2 h; 2: With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 36 h;
参考文献
Griffioen, Gerard; Van Dooren, Tom; Rojas De La Parra, Verónica; Allasia, Sara; Marchand, Arnaud; Kilonda, Amuri; Chaltin, Patrick
Patent: US2013/274260 A1, 2013 ;
Location in patent: Paragraph 0634 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 72 h;
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN Randamp;;D; reMYND; GRIFFIOEN, Gerard; VAN DOOREN, Tom; ROJAS DE LA PARRA, Veronica; MARCHAND, Arnaud; ALLASIA, Sara; KILONDA, Amuri; CHALTIN, Patrick
Patent: WO2010/142801 A1, 2010 ;
Location in patent: Page/Page column 188-189 ;
WO 2010/142801 A1
反应条件
in ethanol; water T=95°C; 1 h;
参考文献
BIOVITRUM AB
Patent: WO2006/122931 A1, 2006 ;
Location in patent: Page/Page column 18-19 ;
WO 2006/122931 A1
反应条件
1.1: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 100 °C 2.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 1 h 3.1: sodium azide / N,N-dimethyl-formamide / 4 h / 70 °C 4.1: triphenylphosphine / methanol / 2 h / 70 °C 4.2: 36 h / 20 °C View Scheme
参考文献
Griffioen, Gerard; Van Dooren, Tom; Rojas De La Parra, Verónica; Allasia, Sara; Marchand, Arnaud; Kilonda, Amuri; Chaltin, Patrick
Patent: US2013/274260 A1, 2013 ;
反应条件
1.1: iodine; silver sulphate / ethanol / 18 h / 20 °C 2.1: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 15 h / 100 °C 3.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 1 h 4.1: sodium azide / N,N-dimethyl-formamide / 4 h / 70 °C 5.1: triphenylphosphine / methanol / 2 h / 70 °C 5.2: 36 h / 20 °C View Scheme
参考文献
Griffioen, Gerard; Van Dooren, Tom; Rojas De La Parra, Verónica; Allasia, Sara; Marchand, Arnaud; Kilonda, Amuri; Chaltin, Patrick
Patent: US2013/274260 A1, 2013 ;
反应条件
1.1: carbon tetrabromide; triphenylphosphine / tetrahydrofuran / 1 h 2.1: sodium azide / N,N-dimethyl-formamide / 4 h / 70 °C 3.1: triphenylphosphine / methanol / 2 h / 70 °C 3.2: 36 h / 20 °C View Scheme
参考文献
Griffioen, Gerard; Van Dooren, Tom; Rojas De La Parra, Verónica; Allasia, Sara; Marchand, Arnaud; Kilonda, Amuri; Chaltin, Patrick
Patent: US2013/274260 A1, 2013 ;
反应条件
1.1: sodium azide / N,N-dimethyl-formamide / 4 h / 70 °C 2.1: triphenylphosphine / methanol / 2 h / 70 °C 2.2: 36 h / 20 °C View Scheme
参考文献
Griffioen, Gerard; Van Dooren, Tom; Rojas De La Parra, Verónica; Marchand, Arnaud; Alassia, Sara; Kilonda, Amuri; Chaltin, Patrick
Patent: US2013/289033 A1, 2013 ;
