1: sulfuric acid / 120 h / Reflux
2: potassium carbonate / acetone / Reflux
3: potassium tert-butylate / tetrahydrofuran / 2 h / 0 °C
4: sodium tetrahydroborate; methanol / 4 h / 0 - 20 °C
View Scheme
参考文献
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
WO 2011/048525 A1