3-氯-2,2,2-三氟苯乙酮合成路线 （共 11 条）
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate 24 h; Reflux;
参考文献
Cheng, Huicheng; Pei, Yu; Leng, Faqiang; Li, Jingya; Liang, Apeng; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng
Tetrahedron Letters, 2013 , vol. 54, # 33 p. 4483 - 4486
反应条件
1: 1-bromo-3-chlorobenzene With iodine; magnesium in tetrahydrofuran 2 h; Heating; 2: N-(trifluoroacetyl)piperidine T=0 - 20°C; 2 h;
参考文献
Schenck, Hilary A.; Lenkowski, Paul W.; Choudhury-Mukherjee, Indrani; Ko, Seong-Hoon; Stables, James P.; Patel, Manoj K.; Brown, Milton L.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 5 p. 979 - 993
反应条件
chlorine; iron(III) chloride
参考文献
Journal of the American Chemical Society, , vol. 73, p. 709
反应条件
in diethyl ether Heating;
参考文献
Journal of the American Chemical Society, , vol. 102, # 12 p. 4167 - 4172
反应条件
1: 1-bromo-3-chlorobenzene With magnesium Metallation; 2: trifluoroacetic anhydride T=-78°C; Grignard reaction;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 70, # 12 p. 3081 - 3090
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 1.2: 4 h / |Acidic conditions 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 24 h / |Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 33 p. 4483 - 4486
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 4 p. 1129 - 1137
反应条件
magnesium ester of trifluoroacetic acid as aduct; Multistep reaction;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 18, p. 317 - 324
Zhurnal Organicheskoi Khimii, , vol. 18, # 2 p. 365 - 373
反应条件
magnesium Multistep reaction;
参考文献
Canadian Journal of Chemistry, , vol. 58, p. 2497 - 2503
反应条件
(i) Mg, Et2O, (ii) /BRN= 1742942/; Multistep reaction;
参考文献
Journal of medicinal chemistry, , vol. 9, # 2 p. 176 - 178
