4'-氯-2,2,2-三氟苯乙酮合成路线 （共 31 条）
反应条件
carbon disulfide; aluminium trichloride
参考文献
Journal of the American Chemical Society, , vol. 77, p. 4164,4167
反应条件
1: With tetra-n-butylammonium acetate in toluene T=0 - 20°C; 1 h; 2: With hydrogenchloride in tetrahydrofuran; toluene
参考文献
Kawano, Yoshikazu; Kaneko, Nobuya; Mukaiyama, Teruaki
Bulletin of the Chemical Society of Japan, 2006 , vol. 79, # 7 p. 1133 - 1145
反应条件
1: 1-chloro-4-bromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2 h; 2: N-(trifluoroacetyl)piperidine in tetrahydrofuran; hexane T=-78 - 20°C; 3 h;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 52 p. 14191 - 14195
Angew. Chem., , vol. 125, # 52 p. 14441 - 14445,5
反应条件
in pyridine T=0°C; 6 h; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 56, # 2 p. 215 - 237
反应条件
1: 98 percent / KOH / ethanol / 20 °C 2: 85 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2 View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8565 - 8571
反应条件
1: 80 percent / tetrahydrofuran / 1 h / -78 °C 2: 98 percent / KOH / ethanol / 20 °C 3: 85 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2 View Scheme
参考文献
Tetrahedron, , vol. 58, # 42 p. 8565 - 8571
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C 1.2: 4 h / |Acidic conditions 2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 22 h / |Reflux View Scheme
参考文献
Tetrahedron Letters, , vol. 54, # 33 p. 4483 - 4486
反应条件
T=0°C; 6 h; Further byproducts given;
参考文献
Journal of Fluorine Chemistry, , vol. 56, # 2 p. 215 - 237
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 4 p. 1129 - 1137
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , p. 591 - 595
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 3 p. 614 - 618
