反应条件
1: 4-Iodo-piperidine-1-carboxylic acid,tert-butyl ester With ethylene dibromide; zinc in tetrahydrofuran
2: With chloro-trimethyl-silane in tetrahydrofuran
3: 2-iodopyrazine With trifuran-2-yl-phosphane; tris(dibenzylideneacetone)dipalladium (0)
T=80°C; Further stages.;
参考文献
Pasternak, Alexander; Goble, Stephen D.; Vicario, Pasquale P.; Di Salvo, Jerry; Ayala, Julia M.; Struthers, Mary; DeMartino, Julie A.; Mills, Sander G.; Yang, Lihu
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 3 p. 994 - 998