1,3-苯并噻唑-2-羧酸乙酯合成路线 （共 33 条）
反应条件
1.1: potassium nitrate; sulfuric acid / 1 h / 10 - 40 °C 2.1: ammonia / methanol / 20 °C 3.1: pyridine; trichlorophosphate / 2.33 h / 0 - 20 °C / Inert atmosphere 3.2: 0 °C View Scheme
参考文献
GRYSHUK, Amy L.; Perkins, Julie; LaTour, John V.
Patent: US2011/224442 A1, 2011 ;
反应条件
1.1: ammonia / methanol / 20 °C 2.1: pyridine; trichlorophosphate / 2.33 h / 0 - 20 °C / Inert atmosphere 2.2: 0 °C View Scheme
参考文献
GRYSHUK, Amy L.; Perkins, Julie; LaTour, John V.
Patent: US2011/224442 A1, 2011 ;
反应条件
ammonia in ethanol 8 h; Reflux;
参考文献
Kamps, Jos J. A. G.; Belle, Roman; Mecinovic, Jasmin
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1103 - 1108
反应条件
1: With diisobutylaluminium hydride in hexanes; dichloromethane T=-50°C; 2: With hydrogenchloride; water in hexanes; dichloromethane; ethyl acetate T=20°C;
参考文献
MEDIVIR AB
Patent: WO2008/107365 A1, 2008 ;
Location in patent: Page/Page column 82 ;
WO 2008/107365 A1
反应条件
1: 2N NaOH / methanol / 2 h / Ambient temperature 2: (COCl)2 / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Romero; Morge; Biles; Berrios-Pena; May; Palmer; Johnson; Smith; Busso; Tan; Voorman; Reusser; Althaus; Downey; So; Resnick; Tarpley; Aristoff
Journal of Medicinal Chemistry, 1994 , vol. 37, # 7 p. 999 - 1014
反应条件
hydrogenchloride T=50°C; overnight;
参考文献
Journal of Heterocyclic Chemistry, , vol. 24, p. 1683 - 1684
反应条件
1: With sodium hydroxide in tetrahydrofuran; water T=20°C; 1 h; 2: With hydrogenchloride in water pH=3;
参考文献
Kamps, Jos J. A. G.; Belle, Roman; Mecinovic, Jasmin
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 7 p. 1103 - 1108
反应条件
1.1: potassium nitrate; sulfuric acid / 1 h / 10 - 40 °C 2.1: ammonia / methanol / 20 °C 3.1: pyridine; trichlorophosphate / 2.33 h / 0 - 20 °C / Inert atmosphere 3.2: 0 °C 4.1: tin(ll) chloride / ethanol / 2 h / 60 °C / Inert atmosphere 4.2: pH 7 View Scheme
参考文献
GRYSHUK, Amy L.; Perkins, Julie; LaTour, John V.
Patent: US2011/224442 A1, 2011 ;
反应条件
hydrazine hydrate in ethanol 0.25 h; Heating;
参考文献
Colautti; Rubessa; Vio
Farmaco, Edizione Scientifica, 1981 , vol. 36, # 4 p. 274 - 282
反应条件
1: NaOEt / benzene 2: H2SO4 / 0.5 h / Heating View Scheme
参考文献
Sawhney; Bansal
Journal of the Indian Chemical Society, 1975 , vol. 52, # 8 p. 740 - 742
