6-吡唑-1-基-烟酸甲酯合成路线 (共 4 条)
反应条件
1: [3,2-c]pyrazole With sodium hydride in dimethyl sulfoxide T=0 - 20°C; 1 h; 2: 2-Chloro-5-pyridinecarboxylic Acid Methyl Ester in dimethyl sulfoxide T=20°C; 6 h;
参考文献
ENANTA PHARMACEUTICALS, INC.
Patent: WO2005/70918 A1, 2005 ;
Location in patent: Page/Page column 40 ;
反应条件
[3,2-c]pyrazole; NaH in dimethyl sulfoxide
参考文献
Xu, Guoyou; Tang, Datong; Gai, Yonghua; Kim, Heejin; Wang, Guoqiang; Phan, Ly Tam; Or, Yat Sun; Wang, Zhe
Patent: US2004/171818 A1, 2004 ;
反应条件
1: With sodium tetrahydroborate; tert-butyl alcohol Heating / reflux; 2: With methanol in tert-butyl alcohol 6 h; Heating / reflux; 3: With hydrogenchloride; water in methanol; tert-butyl alcohol
参考文献
ENANTA PHARMACEUTICALS, INC.
Patent: WO2005/70918 A1, 2005 ;
Location in patent: Page/Page column 40 ;
反应条件
water Acidic aq. solution;
参考文献
Tetrahedron, , vol. 66, # 47 p. 9141 - 9144