2-溴-6-碘-3-甲氧基吡啶合成路线 （共 5 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; 2 h;
参考文献
AVENTIS PHARMA S.A.
Patent: US2008/45561 A1, 2008 ;
Location in patent: Page/Page column 25; 22 ;
反应条件
1: 58 percent / iodine; aq. potassium carbonate / 1.5 h / 20 °C 2: 94 percent / potassium carbonate / dimethylformamide / 2 h / 100 °C View Scheme
参考文献
Organic Letters, , vol. 2, # 26 p. 4201 - 4204
反应条件
in N,N-dimethyl-formamide T=100°C; 1 h;
参考文献
O'Neill, Brian T.; Yohannes, Daniel; Bundesmann, Mark W.; Arnold, Eric P.
Organic Letters, 2000 , vol. 2, # 26 p. 4201 - 4204
反应条件
in N,N-dimethyl-formamide T=100°C; 0.166667 h;
参考文献
MERCK SHARP andamp; DOHME CORP.; COLEMAN, Paul, J.; COX, Christopher, D.; MERCER, Swati, P.; ROECKER, Anthony, J.; SCHREIER, John, D.
Patent: WO2010/51238 A1, 2010 ;
Location in patent: Page/Page column 45-46 ;
WO 2010/051238 A1
反应条件
1: N,N-dimethyl-formamide / 100 °C 2: n-butyllithium / tetrahydrofuran / -78 °C View Scheme
参考文献
Nemecek, Conception; Metz, William A.; Wentzler, Sylvie; Ding, Fa-Xiang; Venot, Corinne; Souaille, Catherine; Dagallier, Anne; Maignan, Sebastien; Guilloteau, Jean-Pierre; Bernard, Francois; Henry, Alain; Grapinet, Sandrine; Lesuisse, Dominique
Chemical Biology and Drug Design, 2010 , vol. 76, # 2 p. 100 - 106
