2-氯-3-甲基苯并(b)噻吩合成路线 （共 37 条）
反应条件
potassium cyanide in dimethyl sulfoxide; Petroleum ether; benzene
参考文献
SRI International
Patent: US5424315 A1, 1995 ;
参考文献
Regents of the University of Minnesota; University of Miami
Patent: US5616575 A1, 1997 ;
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in chloroform 1 h; Heating;
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
参考文献
King; Nord
Journal of Organic Chemistry, 1948 , vol. 13, p. 635,637
反应条件
diethyl ether; magnesium anschliessend Behandlung mit Chlorokohlensaeure-aethylester und Hydrolyse des Reaktionsprodukts;
参考文献
Gaertner
Journal of the American Chemical Society, 1952 , vol. 74, p. 2185,2187
反应条件
1: N-bromosuccinimide / CCl4 / 4 h / Heating; Irradiation 2: aq. sodium carbonate / 2 h / Heating View Scheme
参考文献
Shafiee; Vossoghi; Wossooghi; Yazdani
Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 5 p. 566 - 568
反应条件
1: 28 percent / benzyltriethylammonium chloride / H2O / 1 h / 90 - 95 °C 2: LiAlH4, AlCl3 / diethyl ether / 22 h / Heating View Scheme
参考文献
Efange, Simon M. N.; Mash, Deborah C.; Khare, Anil B.; Ouyang, Quinjie
Journal of Medicinal Chemistry, 1998 , vol. 41, # 23 p. 4486 - 4491
反应条件
1.1: NaH / dimethylformamide; various solvent(s) / 0.5 h / 20 °C 1.2: 80 percent / dimethylformamide; various solvent(s) / 7 h / 20 - 60 °C 2.1: NaOH / methanol / 20 h / 20 °C 3.1: p-xylene / 2 h / Heating 4.1: 75 percent / aq. HCl / 4 h / Heating View Scheme
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
1: diethyl 2-acetylaminomalonate With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.5 h; 2: 3-(chloromethyl)-benzo[b]thiophene in N,N-dimethyl-formamide T=20 - 60°C; 7 h; Further stages.;
参考文献
Podea, Paula Veronica; Tosa, Monica Ioana; Paizs, Csaba; Irimie, Florin Dan
Tetrahedron Asymmetry, 2008 , vol. 19, # 4 p. 500 - 511
反应条件
1: amalgamated magnesium; diethyl ether / Behandeln unter Stickstoff dieser Benzo<b>thiophen-3-yl-methylmagnesium-chlorid-Loesung mit Eis und wss. Ammoniumchlorid-Loesung 2: boron fluoride ether adduct View Scheme
参考文献
Gaertner
Journal of the American Chemical Society, 1952 , vol. 74, p. 2185,2187
