2-氯-3-甲基苯并(b)噻吩合成路线 （共 37 条）
反应条件
1: 62 percent / NaOEt / ethanol 2: 92.9 percent / KOH / H2O 3: 39.3 percent / Acylase Amano 15000, NaOH, CoCl2*6H2O / H2O / 37 °C / pH=7.5 View Scheme
参考文献
Hagiwara, Daijiro; Miyake, Hiroshi; Igari, Norihiro; Karino, Masako; Maeda, Yasue; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 2090 - 2099
反应条件
amalgamated magnesium; diethyl ether Behandeln unter Stickstoff dieser Benzo<b>thiophen-3-yl-methylmagnesium-chlorid-Loesung mit Eis und wss. Ammoniumchlorid-Loesung;
参考文献
Gaertner
Journal of the American Chemical Society, 1952 , vol. 74, p. 2185,2187
反应条件
1,4-dioxane; hydrogenchloride; tin(ll) chloride
参考文献
Gaertner
Journal of the American Chemical Society, 1952 , vol. 74, p. 2185,2187
参考文献
Gaertner
Journal of the American Chemical Society, 1952 , vol. 74, p. 2185,2187
反应条件
1: 62 percent / NaOEt / ethanol 2: 92.9 percent / KOH / H2O 3: 39.3 percent / Acylase Amano 15000, NaOH, CoCl2*6H2O / H2O / 37 °C / pH=7.5 4: 100 percent / Et3N / acetone; H2O View Scheme
参考文献
Hagiwara, Daijiro; Miyake, Hiroshi; Igari, Norihiro; Karino, Masako; Maeda, Yasue; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 13 p. 2090 - 2099
反应条件
1: aqueous acetone 2: aq. NaOH solution View Scheme
参考文献
Avakian et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3075
反应条件
1: aqueous acetone 2: aq. NaOH solution 3: ueber das Saeurechlorid View Scheme
参考文献
Blicke; Sheets
Journal of the American Chemical Society, 1948 , vol. 70, p. 3768,3769
Journal of the American Chemical Society, 1949 , vol. 71, p. 2856,2857
反应条件
1: amalgamated magnesium; diethyl ether / Behandeln unter Stickstoff dieser Benzo<b>thiophen-3-yl-methylmagnesium-chlorid-Loesung mit Eis und wss. Ammoniumchlorid-Loesung 2: boron fluoride ether adduct 3: morpholine; sulfur / Erwaermen des Reaktionsprodukts mit aethanol. Kalilauge View Scheme
参考文献
Gaertner
Journal of the American Chemical Society, 1952 , vol. 74, p. 2185,2187
反应条件
1: benzene
3: >171
View Scheme
参考文献
Cagniant
Bulletin de la Societe Chimique de France, 1949 , p. 382,387
反应条件
1: benzene
2: thionyl chloride; chloroform
View Scheme
参考文献
Nation. Drug. Co.
Patent: US2553495 , 1950 ;
