2-氯-3-甲基苯并(b)噻吩合成路线 （共 37 条）
反应条件
bis(1,5-cyclooctadiene)nickel (0); triethylsilyl trifluoromethanesulphonate; triethylamine; diphenylcyclohexyl phosphine in toluene
T=20°C; Heck type reaction; P=760.051 Torr; 2 h;
参考文献
Matsubara, Ryosuke; Gutierrez, Alicia C.; Jamison, Timothy F.
Journal of the American Chemical Society, 2011 , vol. 133, # 47 p. 19020 - 19023
参考文献
Tominaga, Yoshinori; Lee, Milton L.; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1981 , vol. 18, p. 967 - 972
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate; amidosulfamic acid in N,N-dimethyl-formamide
T=40 - 50°C; Product distribution / selectivity;
参考文献
Abdel-Magid, Ahmed; Mehrman, Steven J; Ferraro, Caterina
Patent: US2009/176996 A1, 2009 ;
Location in patent: Page/Page column 16 ;
反应条件
1: amalgamated magnesium; diethyl ether / Behandeln unter Stickstoff dieser Benzo<b>thiophen-3-yl-methylmagnesium-chlorid-Loesung mit Eis und wss. Ammoniumchlorid-Loesung
2: tetrachloromethane; bromine / Behandeln des Reaktionsprodukts mit wss. Kalilauge
View Scheme
参考文献
Gaertner
Journal of the American Chemical Society, 1952 , vol. 74, p. 2185,2187
反应条件
1: 31 percent / urotropine / CHCl3 / 1 h / Heating
2: 91 percent / toluene / 2 h / Heating
3: 90 percent / aq. KOH / 4 h / Heating
View Scheme
参考文献
Paizs, Csaba; Katona, Adrian; Retey, Janos
Chemistry - A European Journal, 2006 , vol. 12, # 10 p. 2739 - 2744
反应条件
2: 1) NaH / 1) DME, room temperature, 1 h; 2) room temperature, 1 h;
View Scheme
参考文献
Pratap, Ram; Lee, Milton L.; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 219 - 220
反应条件
2: 1) NaH / 1) DME, room temperature, 1 h; 2) room temperature, 1 h;
View Scheme
参考文献
Pratap, Ram; Lee, Milton L.; Castle, Raymond N.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 219 - 220
