苯并[b]噻吩-3-乙腈合成路线 （共 16 条）
反应条件
tetrabutylammomium bromide; palladium diacetate; potassium carbonate in N,N-dimethyl-formamide T=100°C; Heck reaction; 48 h;
参考文献
Dit Chabert, Jeremie Fournier; Joucla, Lionel; David, Emilie; Lemaire, Marc
Tetrahedron, 2004 , vol. 60, # 14 p. 3221 - 3230
反应条件
hydrogenchloride
1.) 10 deg C, 40 h, 2.) reflux, 8 h;
参考文献
Copp, Frederick C.; Franzmann, Karl W.; Gilmore, Jeremy; Whalley, W. Basil
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 5 p. 909 - 914
反应条件
sodium tetrahydroborate; nickel dichloride in methanol
T=45°C; 16.1667 h;
参考文献
BAYER CROPSCIENCE SA
Patent: WO2007/6739 A1, 2007 ;
Location in patent: Page/Page column 73 ;
反应条件
sodium methylate in methanol
T=50 - 60°C; 1 h;
参考文献
SRI International
Patent: US5424315 A1, 1995 ;
反应条件
1: 3-cyanomethylbenzothiophene With sodium ethanolate in ethanol
0.166667 h;
2: pyridine-3-aldehyde in ethanol
T=20°C; 1 h; Darkness;
参考文献
Tcherniuk, Sergey; Skoufias, Dimitrios A.; Labriere, Christophe; Rath, Oliver; Gueritte, Franaoise; Guillou, Catherine; Kozielski, Frank
Angewandte Chemie - International Edition, 2010 , vol. 49, # 44 p. 8228 - 8231
反应条件
potassium tert-butylate in tert-butyl alcohol
T=40°C; 1.33333 h;
参考文献
Shaffiee,A.; Rashidbaigi,A.
Journal of Heterocyclic Chemistry, 1976 , vol. 13, p. 141 - 144
