6-溴-3-羟基-2-吡啶羧酸甲酯合成路线 （共 4 条）
反应条件
bromine in water T=20°C; 3 h;
参考文献
SMITH KLINE BEECHAM CORPORATION a corporation
Patent: US2010/29650 A1, 2010 ;
Location in patent: Page/Page column 65 ;
反应条件
1: sulfuric acid / 24 h / |Reflux 2: bromine / water / 17 h / 0 - 20 °C View Scheme
参考文献
Renou, Julien; Loiodice, Melanie; Arboleas, Melanie; Baati, Rachid; Jean, Ludovic; Nachon, Florian; Renard, Pierre-Yves
Chemical Communications, 2014 , vol. 50, # 30 p. 3947 - 3950
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 4 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/89031 A1, 2007 ;
Location in patent: Page/Page column 84-85 ;
WO 2007/089031 A1
反应条件
in methanol; diethyl ether
T=0°C; 2 h;
参考文献
SPEEDEL EXPERIMENTA AG
Patent: WO2007/31558 A1, 2007 ;
Location in patent: Page/Page column 33 ;
WO 2007/031558 A1
