(1R,2S,4S)-N-BOC-1-氨基-2-羟基环戊烷-4-羧酸甲酯合成路线 （共 10 条）
反应条件
hydrogen; palladium in methanol
反应条件
triethylamine in methanol T=5 - 20°C; 18 h;
参考文献
Smith, Mark E.B.; Lloyd, Michael C.; Derrien, Nadine; Lloyd, Richard C.; Taylor, Stephen J.C.; Chaplin, David A.; Casy, Guy; McCague, Raymond
Tetrahedron Asymmetry, 2001 , vol. 12, # 5 p. 703 - 705
反应条件
1.1: N-bromosuccinimide / tetrahydrofuran; H2O / 17 h / 20 °C 2.1: KOH / H2O; methanol / 48 h / 90 °C 2.2: 40 g / tetrahydrofuran; H2O / 14 h / 20 °C / pH 10.5 3.1: H2 / Pd/C / methanol / 18 h / 20 °C / 1500.15 Torr 4.1: 59 g / triethylamine / methanol / 5 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 3 p. 717 - 728
反应条件
1.1: KOH / H2O; methanol / 48 h / 90 °C 1.2: 40 g / tetrahydrofuran; H2O / 14 h / 20 °C / pH 10.5 2.1: H2 / Pd/C / methanol / 18 h / 20 °C / 1500.15 Torr 3.1: 59 g / triethylamine / methanol / 5 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 3 p. 717 - 728
反应条件
1.1: KOH / H2O; methanol / 48 h / 90 °C 1.2: 40 g / tetrahydrofuran; H2O / 14 h / 20 °C / pH 10.5 2.1: H2 / Pd/C / methanol / 18 h / 20 °C / 1500.15 Torr 3.1: 59 g / triethylamine / methanol / 5 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 3 p. 717 - 728
反应条件
1: H2 / Pd/C / methanol / 18 h / 20 °C / 1500.15 Torr 2: 59 g / triethylamine / methanol / 5 - 20 °C View Scheme
参考文献
Tetrahedron, , vol. 60, # 3 p. 717 - 728
反应条件
1: 97 percent / TEA / CH2Cl2 / 2 h / 0 - 20 °C 2: 38 percent / Oxone; Na2EDTA; Bu4NHSO4 / acetone; aq. phosphate buffer / 5 h / pH 7 3: 100 percent / DBU / CH2Cl2 / 16 h 4: H2 / {[(S,S)-MeDuPHOS]Rh(COD)}BF4 / methanol / 14 h View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 7 p. 1347 - 1350
反应条件
1: 100 percent / DBU / CH2Cl2 / 16 h 2: H2 / {[(S,S)-MeDuPHOS]Rh(COD)}BF4 / methanol / 14 h View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 7 p. 1347 - 1350
反应条件
hydrogen; 1,2-bis((2S,5S)-2,5-dimethylphospholano)benzene(cyclooctadiene)rhodium(I) tetrafluoroborate in methanol 14 h;
参考文献
Tetrahedron Letters, , vol. 42, # 7 p. 1347 - 1350
反应条件
1.1: triethylamine; DMAP / CH2Cl2 / 0.75 h / 0 °C 2.1: KOAc / dimethylformamide / 72 h / 60 °C 2.2: 18.6 g / NaOMe / methanol / 7 h / 0 °C View Scheme
参考文献
Smith, Mark E.B.; Lloyd, Michael C.; Derrien, Nadine; Lloyd, Richard C.; Taylor, Stephen J.C.; Chaplin, David A.; Casy, Guy; McCague, Raymond
Tetrahedron Asymmetry, 2001 , vol. 12, # 5 p. 703 - 705
