4,4,4-三氟-2-甲基-1-苯基-丁烷-1,3-二酮合成路线 （共 6 条）
反应条件
sodium hexamethyldisilazane in tetrahydrofuran
参考文献
Journal of the Chemical Society - Dalton Transactions, , # 4 p. 643 - 647
反应条件
sodium methylate in ethylene glycol dimethyl ether T=20°C; Claisen condensation;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 1 p. 95 - 98
反应条件
1: 1-phenyl-propan-1-one With lithium hexamethyldisilazane in tetrahydrofuran T=0 - 20°C; 0.333333 h; 2: TFETFA in tetrahydrofuran T=20°C; 0.333333 h; 3: With ammonium chloride in tetrahydrofuran; water
参考文献
Journal of Organic Chemistry, , vol. 76, # 10 p. 3676 - 3683
反应条件
1: 75 percent / benzene / 15 h / 10 - 20 °C 2: 18percent aq. HCl / tetrahydrofuran / 2.5 h / 50 °C View Scheme
参考文献
Synthesis, , # 1 p. 117 - 120
反应条件
18-crown-6 ether; potassium carbonate in benzene
T=80°C; 6 h; Reflux;
参考文献
Riofski, Mark V.; John, Jinu P.; Zheng, Mary M.; Kirshner, Julia; Colby, David A.
Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 3676 - 3683
