L-天冬氨酸二甲酯盐酸盐合成路线 （共 14 条）
反应条件
thionyl chloride T=0°C; RefluxInert atmosphere;
参考文献
Fowler, Lindsay S.; Thomas, Lynne H.; Ellis, David; Sutherland, Andrew
Chemical Communications, 2011 , vol. 47, # 23 p. 6569 - 6571
反应条件
thionyl chloride in methanol
参考文献
Regents of the University of California
Patent: US5322942 A1, 1994 ;
反应条件
in methanol T=20°C; 16 h; Cooling with ice; enantioselective reaction;
参考文献
Korpis, Katharina; Weber, Frauke; Brune, Stefanie; Wuensch, Bernhard; Bednarski, Patrick J.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 221 - 233
反应条件
hydrogenchloride T=0 - 20°C; 0.166667 h;
参考文献
WO2005/107762 A2, ;
Page/Page column 268-270 ;
反应条件
in methanol T=-78 - 20°C; 72 h;
参考文献
PFIZER INC.; BAGAL, Sharanjeet Kaur; BROWN, Alan Daniel; KEMP, Mark Ian; KLUTE, Wolfgang; MARRON, Brian Edward; MILLER, Duncan Charles; SKERRATT, Sarah Elizabeth; SUTO, Mark J.; WEST, Christopher William; MALET SANZ, Laia
Patent: WO2013/114250 A1, 2013 ;
Location in patent: Page/Page column 168 ;
反应条件
acetyl chloride T=5 - 10°C; Cooling with ice;
参考文献
WO2010/105367 A1, ;
Page/Page column 35; 36; 37 ;
反应条件
hydrogenchloride in water
参考文献
Synlett, , # 17 p. 2803 - 2808
反应条件
thionyl chloride Ambient temperature;
参考文献
Heterocycles, , vol. 32, # 10 p. 1879 - 1895
反应条件
e.e. = 95percent; Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 28, # 11 p. 1215 - 1218
反应条件
1: With dicyclohexyl-carbodiimide in tetrahydrofuran T=-10 - 5°C; 2: With acetic acid in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Deutsches Krebsforschungszentrum Stiftung des oeffentlichen Rechts
Patent: EP1647283 A1, 2006 ;
Location in patent: Page/Page column 5-6 ;
