反应条件
1: 1.) zinc dust, Ph3P 2.) pyridine / 1.) CH2Cl2, 15 min, r.t. 2.) CH2Cl2, 30 min r.t. 2: 91 percent / n-butyllithium / hexane; tetrahydrofuran / -78 to 20 deg C 3: 91 percent / Et3N / bis-triphenylphosphine palladium dichloride / dimethylformamide / 1.5 h / 75 °C 4: 95 percent / H2 / Lindlar's catalyst, quinoline / hexane / 0.75 h 5: 2.) AG 50W-X4 resin / 1.) iso-octane, 4 h, reflux 2.) methanol, CH2Cl2, 24 h, r.t. 6: 80 percent / diethyl ether / 0.33 h / -78 °C View Scheme
参考文献
Tetrahedron, , vol. 47, # 20-21 p. 3485 - 3498
