(-)-6beta-羟甲基-7alpha-羟基-顺式-2-氧杂双环[3.3.0]辛-3-酮合成路线 （共 65 条）
反应条件
1: With sodium methylate in methanol T=20°C; 1.5 h; 2: With hydrogenchloride in 1,4-dioxane; methanol T=20°C; pH=3 - 4;
参考文献
Alphora Research Inc.
Patent: US2010/56807 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
CuSO4‵5H2O in methanol T=100°C; 0.25 h; Microwave irradiation;
参考文献
Gonzalez-Calderon, Davir; Benitez-Puebla, Luis J.; Gonzalez-Gonzalez, Carlos A.; Assad-Hernandez, Salomon; Fuentes-Benitez, Aydee; Cuevas-Yanez, Erick; Corona-Becerril, David; Gonzalez-Romero, Carlos
Tetrahedron Letters, 2013 , vol. 54, # 37 p. 5130 - 5132
反应条件
Amberlite IR 120 resin in methanol T=70°C; 8 h;
参考文献
Toemoeskoezi, Istvan; Gruber, Lajos; Baitz-Gacs, Eszter
Tetrahedron, 1992 , vol. 48, # 47 p. 10345 - 10352
反应条件
hydrogen; palladium on activated charcoal in dichloromethane T=20°C; 0.833333 h; atmospheric pressure;
参考文献
Kim, Seongjin; Jacobo, Sheila Marie; Chang, Chih-Tsung; Bellone, Sophie; Powell, William S.; Rokach, Joshua
Tetrahedron Letters, 2004 , vol. 45, # 9 p. 1973 - 1976
反应条件
Amberlite IR 120 resin in methanol T=70°C; 8 h;
参考文献
Toemoeskoezi, Istvan; Gruber, Lajos; Baitz-Gacs, Eszter
Tetrahedron, 1992 , vol. 48, # 47 p. 10345 - 10352
反应条件
Amberlite IR 120 resin in methanol T=70°C; 8 h;
参考文献
Toemoeskoezi, Istvan; Gruber, Lajos; Baitz-Gacs, Eszter
Tetrahedron, 1992 , vol. 48, # 47 p. 10345 - 10352
反应条件
toluene-4-sulfonic acid in methanol T=75 - 80°C; 4 h;
参考文献
Toemoeskoezi, Istvan; Gruber, Lajos; Baitz-Gacs, Eszter
Tetrahedron, 1992 , vol. 48, # 47 p. 10345 - 10352
反应条件
potassium carbonate in methanol; dichloromethane 3 h; Ambient temperature;
参考文献
Zak, Bohumil; Vesely, Ivan; Neumitka, Karel; Palecek, Jaroslav
Collection of Czechoslovak Chemical Communications, 1991 , vol. 56, # 8 p. 1690 - 1700
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene Heating; Further byproducts given;
参考文献
Synthesis, , # 4 p. 569 - 580
反应条件
1: 92 percent / conc. sulfuric acid / 1.) 80 deg C, 5 h, 2.) RT, 12 h 2: 6.2 g / sodium / methanol / 0.5 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 26, # 7.1 p. 1274 - 1280
Zhurnal Organicheskoi Khimii, , vol. 26, # 7 p. 1476 - 1484
