1: methyl pyridin-2-yl ketone With 1-n-butyl-3-methylimidazolium tetrafluoroborate; sodium hydroxide 0.166667 h; Cooling with iceIonic liquid; 2: pyridine-2-carbaldehyde T=0°C; 2 h; Ionic liquid; 3: With ammonium acetate T=110°C; 2 h; Ionic liquid;

ammonium acetate; acetic acid T=100°C; modified Kroehnke synthesis; 16 h;

1: 100 percent / I2 2: ammonium acetate / methanol View Scheme

ammonium acetate in methanol

1.1: potassium hydroxide / methanol; water / 0 °C 1.2: 3 h / 0 °C 2.1: ammonium acetate; acetic acid / 16 h / 100 °C View Scheme