5-((叔丁基二甲基甲硅烷基氧基)甲基)吡啶-2-胺合成路线 （共 4 条）
反应条件
N-ethyl-N,N-diisopropylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane; N,N-dimethyl-formamide T=0 - 20°C; 20 h;
参考文献
METABASIS THERAPEUTICS, INC.
Patent: WO2009/23718 A2, 2009 ;
Location in patent: Page/Page column 125-127 ;
WO 2009/023718 A2
反应条件
hydroxylamine in methanol; water T=20°C; 16 h;
参考文献
NOVARTIS AG; ASTEX THERAPEUTICS LTD.; BESONG, Gilbert; BRAIN, Christopher Thomas; BROOKS, Clinton A.; CONGREVE, Miles Stuart; DAGOSTIN, Claudio; HE, Guo; HOU, Ying; HOWARD, Steven; LI, Yue; LU, Yipin; MORTENSON, Paul; SMITH, Troy; SUNG, Moo; WOODHEAD, Steven; WRONA, Wojciech
Patent: WO2010/20675 A1, 2010 ;
Location in patent: Page/Page column 73; 74 ;
WO 2010/020675 A1
反应条件
1: thionyl chloride / 0 °C / |Reflux 2: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere 3: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C View Scheme
参考文献
Gruenenthal GmbH; FRANK, Robert; Christoph, Thomas; Lesch, Bernhard; Lee, Jeewoo
Patent: US2013/29961 A1, 2013 ;
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / |Inert atmosphere 2: 1H-imidazole / N,N-dimethyl-formamide / 5 h / 20 °C View Scheme
参考文献
Gruenenthal GmbH; FRANK, Robert; Christoph, Thomas; Lesch, Bernhard; Lee, Jeewoo
Patent: US2013/29961 A1, 2013 ;
