2-((吡啶-4-基)甲基)丙酸合成路线 （共 4 条）
反应条件
1: With hydrogenchloride; water 16 h; Reflux; 2: With sodium hydrogencarbonate in water pH=6;
参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
Location in patent: Page/Page column 26 ;
US 20110224225 A1
反应条件
hydrogenchloride in diethyl 2-methyl-2-(pyridin-4-ylmethyl)malonate; N,N-dimethyl-formamide
参考文献
Ban, Masakazu; Suhara, Hiroshi; Horiuchi, Masato; Yamamoto, Noriyoshi; Enomoto, Hiroshi
Patent: US2003/32623 A1, 2003 ;
反应条件
sodium borohydride; iodine in tetrahydrofuran; water
参考文献
Ban, Masakazu; Suhara, Hiroshi; Horiuchi, Masato; Yamamoto, Noriyoshi; Enomoto, Hiroshi
Patent: US2003/32623 A1, 2003 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 16 h / 0 - 20 °C 2.1: hydrogenchloride; water / 16 h / Reflux 2.2: pH 6 View Scheme
参考文献
Zeitlmann, Lutz; Niestroj, Andre; Heiser, Ulrich
Patent: US2011/224225 A1, 2011 ;
US 20110224225 A1
