N2-乙基-2,3-吡啶二胺合成路线 （共 12 条）
反应条件
in methanol; Pd(OH)2/C
参考文献
Boehringer Ingelheim (Canada) Ltd.
Patent: US2004/106791 A1, 2004 ;
Location in patent: Page 8 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 0.5 h; Heating;
参考文献
Zecchini; Torrini; Paradisi
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 2 p. 313 - 318
反应条件
1: xylene / 3 h / 105 °C 2: 28 g / SnCl2*2H2O, conc. HCl, AcOH / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 16 p. 2960 - 2971
反应条件
in hydrogenchloride; water; acetic acid
反应条件
in hydrogenchloride; water; acetic acid
反应条件
1: 60 percent / pyridine / tetrahydrofuran / 0 deg C, 15 min, then room temperature, 3 h 2: 100 percent / pyridine / Ambient temperature; overnight 3: 100 percent / H2 / 5percent Pd/alumina / CH2Cl2 / 5 h 4: 91 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 2 p. 313 - 318
反应条件
1: 100 percent / pyridine / Ambient temperature; overnight 2: 100 percent / H2 / 5percent Pd/alumina / CH2Cl2 / 5 h 3: 91 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 2 p. 313 - 318
反应条件
1: 100 percent / H2 / 5percent Pd/alumina / CH2Cl2 / 5 h 2: 91 percent / LiAlH4 / tetrahydrofuran / 0.5 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, # 2 p. 313 - 318
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran Ambient temperature;
参考文献
Klunder, Janice M.; Hoermann, MaryAnn; Cywin, Charles L.; David, Eva; Brickwood, Janice R.; Schwartz, Racheline; Barringer, Kevin J.; Pauletti, Daniel; Shih, Cheng-Kon; Erickson, David A.; Sorge, Christopher L.; Joseph, David P.; Hattox, Susan E.; Adams, Julian; Grob, Peter M.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 16 p. 2960 - 2971
反应条件
sodium hydrogencarbonate in acetonitrile
参考文献
Boehringer Ingelheim International GmbH
Patent: US2003/195197 A1, 2003 ;
