3-甲基-1-戊烯-4-炔-3-醇合成路线 （共 33 条）
反应条件
1: MgSO4, BF3*Et2O / 1 h / 5 °C 2: 1.) 1.5 M BuLi / 1.) THF/hexane, -30 deg C, 2.) THF/hexane, 2 h, room temperature 3: 97 percent / hydrogen / Lindlar-catalyst, 1,2-bis<(2-hydroxyethyl)thio>ethane / ethanol / 4 h / Ambient temperature 4: 65 percent / TsOH*H2O / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Soukup; Broger; Widmer
Helvetica Chimica Acta, 1989 , vol. 72, # 2 p. 370 - 376
反应条件
1: 33 percent Spectr. / 1.2 equiv. H2 / 5percent Pd/CaCO3/Pb / hexane / or with 5percentPd/C/quinoline in pentane, -30 deg C or 0 deg C 2: 1 percent Spectr. / triethylamine / <RhCl(COD)>2 / acetonitrile; H2O / 16 h / 100 °C / 30002.4 Torr View Scheme
参考文献
Eilbracht, Peter; Huettmann, Gerd-Erich; Deussen, Rainer
Chemische Berichte, 1990 , vol. 123, # 5 p. 1063 - 1070
反应条件
hydrogen; palladium in ethanol T=29.9°C; P=15001.2 Torr; different catalysts (group VIII);
参考文献
Sokolo'skii, D. V.; Zhubanova, L. K.; Omarkulov, T. O.; Sadykov, U. A.; Korolev, A. V.
Russian Journal of Physical Chemistry, 1990 , vol. 64, # 1 p. 43 - 46
Zhurnal Fizicheskoi Khimii, 1990 , vol. 64, # 1 p. 83 - 87
反应条件
N-bromosuccinmide; silver nitrate in acetone T=20°C; Inert atmosphere;
参考文献
Shu, Xing-Zhong; Li, Xiaoxun; Shu, Dongxu; Huang, Suyu; Schienebeck, Casi M.; Zhou, Xin; Robichaux, Patrick J.; Tang, Weiping
Journal of the American Chemical Society, 2012 , vol. 134, # 11 p. 5211 - 5221
反应条件
hydrogen; palladium in ethanol T=29.9°C; P=15001.2 Torr; different catalysts (group VIII);
参考文献
Sokolo'skii, D. V.; Zhubanova, L. K.; Omarkulov, T. O.; Sadykov, U. A.; Korolev, A. V.
Russian Journal of Physical Chemistry, 1990 , vol. 64, # 1 p. 43 - 46
Zhurnal Fizicheskoi Khimii, 1990 , vol. 64, # 1 p. 83 - 87
反应条件
1: 81 percent / aq. H2SO3 / 2 h / 50 °C View Scheme
参考文献
Gabriele; Salerno; Lauria
Journal of Organic Chemistry, 1999 , vol. 64, # 21 p. 7687 - 7692
反应条件
acid Allylic Rearrangement;
参考文献
EP1167331 A2, ;
Scheme 2 ;
参考文献
DSM IP ASSETS B.V.
Patent: WO2008/77543 A1, 2008 ;
Location in patent: Page/Page column 17-18 ;
反应条件
sodium hydride 1.) diethyl ether, 1h, reflux, 2.) ether, 1h, reflux; Yield given. Multistep reaction;
参考文献
Schienebeck, Casi M.; Robichaux, Patrick J.; Li, Xiaoxun; Chen, Lianqing; Tang, Weiping
Chemical Communications, 2013 , vol. 49, # 26 p. 2616 - 2618
反应条件
1: 81 percent / aq. H2SO3 / 2 h / 50 °C 2: 87 percent / KI / PdI2 / 18 h / 25 °C View Scheme
参考文献
Gabriele; Salerno; Lauria
Journal of Organic Chemistry, 1999 , vol. 64, # 21 p. 7687 - 7692
