3-(4-氯苯基)-丙腈合成路线 （共 15 条）
反应条件
di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium; 1,3-bis-(diphenylphosphino)propane; caesium carbonate in toluene T=150°C; indirect Wittig reaction; 72 h;
参考文献
Angewandte Chemie - International Edition, , vol. 41, # 24 p. 4740 - 4743
反应条件
1,3-bis-(diphenylphosphino)propane; caesium carbonate; di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium in toluene T=150°C; 72 h;
参考文献
Black, Phillip J.; Edwards, Michael G.; Williams, Jonathan M. J.
European Journal of Organic Chemistry, 2006 , # 19 p. 4367 - 4378
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 9 h;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 1 p. 55 - 69
反应条件
samarium diiodide in tetrahydrofuran; methanol T=60°C; Reduction; desulfonylation; 4 h;
参考文献
Guo, Hongyun; Zhang, Yongmin
Synthetic Communications, 2000 , vol. 30, # 11 p. 1879 - 1885
反应条件
1: With caesium carbonate T=180°C; 0.333333 h; Microwave irradiationInert atmosphere; 2: With di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium T=180°C; 0.666667 h; Microwave irradiationInert atmosphere;
参考文献
Anxionnat, Bruno; Gomez Pardo, Domingo; Ricci, Gino; Cossy, Janine
Organic Letters, 2011 , vol. 13, # 15 p. 4084 - 4087
反应条件
in dimethyl sulfoxide T=80°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 8 p. 2426 - 2431
反应条件
nickel in ethylene glycol dimethyl ether T=85°C; 0.25 h;
参考文献
Inaba, Shin-ichi; Rieke, Reuben D.
Synthesis, 1984 , # 10 p. 842 - 844
反应条件
1: (4-chloro-phenyl)-acetic acid With indium tribromide; 1,1,3,3-tetramethyldisiloxane; iodine in chloroform T=60°C; Inert atmosphere; 2: trimethylsilyl cyanide With tetrabutyl ammonium fluoride in tetrahydrofuran; chloroform T=60°C; 5 h; Inert atmosphere; Reagent/catalyst; chemoselective reaction;
参考文献
Moriya, Toshimitsu; Shoji, Kohei; Yoneda, Shinichiro; Ikeda, Reiko; Konakahara, Takeo; Sakai, Norio
Synthesis (Germany), 2013 , vol. 45, # 23 p. 3233 - 3238
反应条件
1: With N-ethyl-N,N-diisopropylamine; anhydrous propionitrile T=97°C; 24 h; 2: With water T=97°C; 4 h; Further stages.;
参考文献
Zaragoza, Florencio
Journal of Organic Chemistry, 2002 , vol. 67, # 14 p. 4963 - 4964
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 13 p. 3569 - 3573
