2,2-二甲基-6-乙酰基苯并二氢吡喃合成路线 （共 15 条）
反应条件
AlCl3, aluminium chloride in dichloromethane T=20°C; 0.5 h;
参考文献
Jetson, Rachael; Malik, Neha; Luniwal, Amarjit; Chari, Venkatesh; Ratnam, Manohar; Erhardt, Paul
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 104 - 108
反应条件
bismuth trifluoromethanesulphonate in toluene T=40°C; 18 h; Inert atmosphereSealed tube;
参考文献
Judd, Katie E.; Caggiano, Lorenzo
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 14 p. 5201 - 5210
反应条件
hydrogenchloride in ethanol; water 5 h; Reflux;
参考文献
Lizarraga, Emilio; Gil, Diego M.; Echeverria, Gustavo A.; Piro, Oscar E.; Catalan, Cesar A.N.; Ben Altabef, Aida
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2014 , vol. 127, p. 74 - 84
反应条件
sodium hydroxide in methanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-benzene
参考文献
E. R. Squibb and Sons, Inc.
Patent: US5276168 A1, 1994 ;
反应条件
toluene-4-sulfonic acid in toluene Heating;
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
反应条件
1: 100 percent / 15percent aq. H2SO4 / benzene / 2 h / 105 °C 2: 54 percent / AlCl3 / CH2Cl2 / 0.5 h / Ambient temperature View Scheme
参考文献
Jetson, Rachael; Malik, Neha; Luniwal, Amarjit; Chari, Venkatesh; Ratnam, Manohar; Erhardt, Paul
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 104 - 108
反应条件
1: I2, CF3CO2Ag / CHCl3 / Ambient temperature 2: 84 percent / PPh3, Et3N, PdCl2, CuI / dimethylformamide / 1 h / 85 °C 3: H2 / Raney Ni / methanol / 20 °C 4: 87 percent / TsOH*H2O / toluene / Heating View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
反应条件
1: 84 percent / PPh3, Et3N, PdCl2, CuI / dimethylformamide / 1 h / 85 °C 2: H2 / Raney Ni / methanol / 20 °C 3: 87 percent / TsOH*H2O / toluene / Heating View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
反应条件
1: H2 / Raney Ni / methanol / 20 °C 2: 87 percent / TsOH*H2O / toluene / Heating View Scheme
参考文献
Tsukayama, Masao; Kikuchi, Makoto; Kawamura, Yasuhiko
Heterocycles, 1994 , vol. 38, # 7 p. 1487 - 1490
反应条件
Montmorillonite K10 clay in tetrachloromethane 2 h;
参考文献
Dintzner, Matthew R.; McClelland, Kristen M.; Morse, Kara M.; Akroush, Michael H.
Synlett, 2004 , # 11 p. 2028 - 2030
