2,2-二甲基-6-乙酰基苯并二氢吡喃合成路线 （共 15 条）
反应条件
sodium hydroxide; sodium hypochlorite in 1,4-dioxane T=65°C; 96 h;
参考文献
Teng, Min; Duong, Tien T.; Johnson, Alan T.; Klein, Elliott S.; Wang, Liming; Khalifa, Berket; Chandraratna, Roshantha A. S.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 16 p. 2445 - 2451
反应条件
sodium hydroxide; I2 in 1,4-dioxane; tetrachloromethane
参考文献
Allergan Sales, Inc.
Patent: US5877207 A1, 1999 ;
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 23, # 11 p. 1124 - 1125
反应条件
1: 85 percent / NBS
2: 90 percent / KBH4
View Scheme
参考文献
Ahluwalia, V. K.; Mukherjee, Irani; Mukherjee, Keya
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 11 p. 1124 - 1125
反应条件
1: 92 percent / 5.25percent aq. NaOCl, NaOH / dioxane / 96 h / 65 °C
2: 100 percent / H2SO4 / 95 °C
View Scheme
参考文献
Jetson, Rachael; Malik, Neha; Luniwal, Amarjit; Chari, Venkatesh; Ratnam, Manohar; Erhardt, Paul
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 104 - 108
