6-甲基吡啶-3-氨基甲酸叔丁酯合成路线 （共 6 条）
反应条件
1: 5-Amino-2-methylpyridine With lithium hexamethyldisilazane in tetrahydrofuran T=20°C; 0.25 h; 2: di-tert-butyl dicarbonate in tetrahydrofuran T=20°C; 17 h;
参考文献
AMGEN INC.; D'AMICO, Derin C.; HERBERICH, Bradley J.; JACKSON, Claire L.M.; PETTUS, Liping H.; TASKER, Andrew; WANG, Hui-Ling; WU, Bin; WURZ, Ryan
Patent: WO2012/148775 A1, 2012 ;
Location in patent: Page/Page column 113; 114 ;
WO 2012/148775 A1
反应条件
diphenyl phosphoryl azide; triethylamine in 1,4-dioxane T=20°C; 18 h; Heating / reflux; Product distribution / selectivity;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 29-30 ;
反应条件
palladium diacetate; caesium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in 1,4-dioxane T=100°C; 24 h;
参考文献
Qin, Lijin; Cui, Hongmeng; Zou, Dapeng; Li, Jingya; Wu, Yangjie; Zhu, Zhiwu; Wu, Yusheng
Tetrahedron Letters, 2010 , vol. 51, # 33 p. 4445 - 4448
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in chloroform T=20°C; 1.5 h; 2: With acetic anhydride T=100°C; 0.5 h; 3: With potassium carbonate in methanol T=20°C; 15 h; Further stages.;
参考文献
Mitsuya; Kobayashi; Kawakami; Satoh; Ogino; Kakikawa; Ohtake; Kimura; Hirose; Sato; Numazawa; Hasegawa; Noguchi; Mase
Journal of Medicinal Chemistry, 2000 , vol. 43, # 26 p. 5017 - 5029
反应条件
1: With hydrogenchloride in water T=0°C; 0.5 h; 2: With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 0.75 h; 3: With hydrogenchloride; sodium hydroxide; tin(ll) chloride Product distribution / selectivity; more than 3 stages;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1785418 A1, 2007 ;
Location in patent: Page/Page column 30 ;
反应条件
hydrogen; acetic acid; platinum(IV) oxide in ethanol T=50°C; P=2844.39 Torr; 72 h;
参考文献
PFIZER INC.; NINKOVIC, Sacha; BRAGANZA, John Frederick; COLLINS, Michael Raymond; KATH, John Charles; LI, Hui; RICHTER, Daniel Tyler
Patent: WO2010/16005 A1, 2010 ;
Location in patent: Page/Page column 135-136 ;
WO 2010/016005 A1
