反应条件
1.1: 77 percent / N-bromosuccinimide; PPh3(polystyrene-bound) / CH2Cl2 / 1 h / 20 °C
2.1: NaH / dimethylformamide / 0.5 h / 20 °C
2.2: dimethylformamide / 1 h / 80 °C
3.1: 253 mg / lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 60 °C
4.1: Et3N; bis(oxo-3-oxazolidinyl)phosphoryl chloride / CH2Cl2 / 0.5 h / 20 °C
4.2: 60 percent / CH2Cl2 / 16 h / 20 °C
View Scheme
参考文献
Nazare, Marc; Essrich, Melanie; Will, David W.; Matter, Hans; Ritter, Kurt; Urmann, Matthias; Bauer, Armin; Schreuder, Herman; Dudda, Angela; Czech, Joerg; Lorenz, Martin; Laux, Volker; Wehner, Volkmar
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 16 p. 4191 - 4195
