5-吡啶-2-基-1,2-二氢-1,2,4-三唑-3-硫酮合成路线 （共 3 条）
反应条件
1: pyridine-2-carboxylic acid With benzotriazol-1-ol; diisopropyl-carbodiimide in tetrahydrofuran T=20°C; 2: thiosemicarbazide in tetrahydrofuran T=100°C; 0.0833333 h; microwave irradiation; 3: With sodium hydroxide in ethanol; water T=150°C; 0.166667 h; microwave irradiation;
参考文献
GLAXO GROUP LIMITED
Patent: WO2009/87218 A1, 2009 ;
Location in patent: Page/Page column 39 ;
WO 2009/087218 A1
反应条件
potassium hydroxide in methanol 4 h; Heating;
参考文献
Orlewska, Czeslawa; Pancechowska-Ksepko, Danuta; Foks, Henryk; Zwolska, Zofia; Augustynowicz-Kopec, Ewa
Phosphorus, Sulfur and Silicon and the Related Elements, 2006 , vol. 181, # 4 p. 737 - 744
反应条件
1: acetone / Ambient temperature 2: ethanol / 12 h / Ambient temperature 3: pyridine / 115 °C View Scheme
参考文献
Santus, Maria; Kaczynski, Jacek; Strauss, Krystyna; Wenda, Malgorzata
Acta Poloniae Pharmaceutica, 1993 , vol. 50, # 4-5 p. 331 - 336
