(8R)-8-乙酰基-7,8,9,10-四氢-6,8,11-三羟基-1-甲氧基-5,12-并四苯醌合成路线 （共 36 条）
反应条件
sodium dithionite in water; dimethyl sulfoxide T=20°C; 72 h; other reducing agents, other time; Product distribution;
参考文献
Gaudiano, Giorgio; Frigerio, Massimo; Bravo, Pierfrancesco; Koch, Tad H.
Journal of the American Chemical Society, 1992 , vol. 114, # 8 p. 3107 - 3113
反应条件
3,5,5-trimethyl-2-oxomorpholin-3-yl radical in dimethyl sulfoxide T=40°C;
参考文献
Kleyer, Don L.; Koch, Tad H.
Journal of the American Chemical Society, 1984 , vol. 106, # 8 p. 2380 - 2387
反应条件
sodium dithionite in water
参考文献
Bird; Gaudiano; Koch
Journal of the American Chemical Society, 1991 , vol. 113, # 1 p. 308 - 315
反应条件
trifluoroacetic acid T=50 - 55°C; 7.5 h;
参考文献
Fujioka; Yamamoto; Annoura; Miyazaki; Kita
Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 7 p. 1872 - 1876
反应条件
1: Tris, Tris*HCl / methanol 2: methanol / 25.1 °C / var. temperature, solvent CH3OD; deuterium kinetic isotope effect View Scheme
参考文献
Bird, Donald M.; Boldt, Marybeth; Koch, Tad H.
Journal of the American Chemical Society, 1989 , vol. 111, # 3 p. 1148 - 1150
反应条件
pyridine; hydrogen; palladium on activated charcoal
参考文献
Sulikowski, Gary A.; Turos, Edward; Danishefsky, Samuel J.; Shulte, Gayle M.
Journal of the American Chemical Society, 1991 , vol. 113, # 4 p. 1373 - 1377
反应条件
1: 3,5,5-trimethyl-2-oxo-morpholin-3-yl radical / dimethylsulfoxide / 40 °C 2: Tris, Tris*HCl / methanol / 25.3 °C / var. solvent CH3OD; deuterium kinetic isotope effect View Scheme
参考文献
Kleyer, Don L.; Koch, Tad H.
Journal of the American Chemical Society, 1984 , vol. 106, # 8 p. 2380 - 2387
反应条件
1: 4-dimethylaminopyridine (DMAP), pyridine, H2 / 10percent Pd/C / 0.25 h 2: 4-dimethylaminopyridine, pyridine / 20 h 3: 1.) 0.1 N aq. LiOH, 2.) O2 / 1.) THF, 14 h, 2.) 3 min 4: H2, pyridine / 10percent Pd/C View Scheme
参考文献
Sulikowski, Gary A.; Turos, Edward; Danishefsky, Samuel J.; Shulte, Gayle M.
Journal of the American Chemical Society, 1991 , vol. 113, # 4 p. 1373 - 1377
反应条件
1: 1.) 0.1 N aq. LiOH, 2.) O2 / 1.) THF, 14 h, 2.) 3 min 2: H2, pyridine / 10percent Pd/C View Scheme
参考文献
Sulikowski, Gary A.; Turos, Edward; Danishefsky, Samuel J.; Shulte, Gayle M.
Journal of the American Chemical Society, 1991 , vol. 113, # 4 p. 1373 - 1377
反应条件
sodium methylate in tetrahydrofuran T=20°C; 5 h; other reagent: potassium carbonate;
参考文献
Sallam; Whistler; Cassady
Canadian Journal of Chemistry, 1985 , vol. 63, # 10 p. 2697 - 2702
