2-甲基-7-(三氟甲基)喹啉合成路线 (共 2 条)
反应条件
hydrogenchloride in water 3 h; Reflux;
参考文献
ARRAY BIOPHARMA INC.; BLAKE, James, F; DELISLE, Robert, Kirk; DE MEESE, Lisa, A.; GRAHAM, James, M.; LE HUEROU, Yvan; LYON, Michael; ROBINSON, John, E.; WALLACE, Eli, M.; WANG, Bin; XU, Rui
Patent: WO2012/154274 A1, 2012 ;
Location in patent: Page/Page column 87-88 ;
WO 2012/154274 A1
反应条件
hydrogenchloride Doebner-Miller reaction; 2 h; Heating;
参考文献
Polanski, Jaroslaw; Zouhiri, Fatima; Jeanson, Laurence; Desmaele, Didier; D'Angelo, Jean; Mouscadet, Jean-Francois; Gieleciak, Rafal; Gasteiger, Johann; Le Bret, Marc
Journal of Medicinal Chemistry, 2002 , vol. 45, # 21 p. 4647 - 4654