2-(4-氟苯基)-5-苯基-1,3-恶唑合成路线 （共 20 条）
反应条件
2,6-dimethylpyridine in toluene T=80°C; Inert atmosphere;
参考文献
Dos Santos, Aurelie; El Kaim, Laurent; Grimaud, Laurence; Ronsseray, Caroline
Chemical Communications, 2009 , # 26 p. 3907 - 3909
反应条件
1: 84.7 percent / CH2Cl2 / 1 h / 20 °C 2: 85 percent / aq. HCl / ethanol / 72 h / 20 °C 3: 73.1 percent / pyridine / 2 h / Heating 4: 77.5 percent / POCl3 / 3 h / Heating View Scheme
参考文献
Meyer, Hans-Joachim; Wolff, Thomas
Chemistry - A European Journal, 2000 , vol. 6, # 15 p. 2809 - 2817
反应条件
[(tris(3,5-dimethylpyrazolylmethyl)amine)Cu]PF6 T=40°C; 24 h; Inert atmosphereSchlenk technique;
参考文献
Haldon, Estela; Besora, Maria; Cano, Israel; Cambeiro, Xacobe C.; Pericas, Miquel A.; Maseras, Feliu; Nicasio, M. Carmen; Perez, Pedro J.
Chemistry - A European Journal, 2014 , vol. 20, # 12 p. 3463 - 3474
反应条件
1: 73.1 percent / pyridine / 2 h / Heating 2: 77.5 percent / POCl3 / 3 h / Heating View Scheme
参考文献
Meyer, Hans-Joachim; Wolff, Thomas
Chemistry - A European Journal, 2000 , vol. 6, # 15 p. 2809 - 2817
反应条件
1: 73.1 percent / pyridine / 2 h / Heating 2: 77.5 percent / POCl3 / 3 h / Heating View Scheme
参考文献
Meyer, Hans-Joachim; Wolff, Thomas
Chemistry - A European Journal, 2000 , vol. 6, # 15 p. 2809 - 2817
反应条件
1: iodine; water / dimethyl sulfoxide / 100 °C 2: iodine / dimethyl sulfoxide / 100 °C View Scheme
参考文献
Gao, Qing-He; Fei, Zhuan; Zhu, Yan-Ping; Lian, Mi; Jia, Feng-Cheng; Liu, Mei-Cai; She, Neng-Fang; Wu, An-Xin
Tetrahedron, 2013 , vol. 69, # 1 p. 22 - 28
反应条件
1: iodine / dimethyl sulfoxide / 100 °C 2: iodine / dimethyl sulfoxide / 100 °C View Scheme
参考文献
Gao, Qing-He; Fei, Zhuan; Zhu, Yan-Ping; Lian, Mi; Jia, Feng-Cheng; Liu, Mei-Cai; She, Neng-Fang; Wu, An-Xin
Tetrahedron, 2013 , vol. 69, # 1 p. 22 - 28
反应条件
1: toluene-4-sulfonic acid / toluene / 24 h / |Reflux 2: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C 3: trimethylsilyl trifluoromethanesulfonate; bis-[(trifluoroacetoxy)iodo]benzene / dichloromethane; diethyl ether / -78 - 0 °C View Scheme
参考文献
Hempel, Christian; Nachtsheim, Boris J.
Synlett, 2013 , vol. 24, # 16 art. no. ST-2013-D0547-L, p. 2119 - 2123
反应条件
1: toluene-4-sulfonic acid / toluene / 24 h / |Reflux 2: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C 3: trimethylsilyl trifluoromethanesulfonate; bis-[(trifluoroacetoxy)iodo]benzene / dichloromethane; diethyl ether / -78 - 0 °C View Scheme
参考文献
Hempel, Christian; Nachtsheim, Boris J.
Synlett, 2013 , vol. 24, # 16 art. no. ST-2013-D0547-L, p. 2119 - 2123
反应条件
1: potassium carbonate; copper(l) iodide; N-methyl-2-(methylamino)ethylamine / tetrahydrofuran / 18 h / 80 °C / |Inert atmosphere 2: copper(ll) bromide; tetrabutylammomium bromide; dipotassium peroxodisulfate; 3-pyridinecarboxylic acid ethyl ester / acetonitrile / 24 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Cheung, Chi Wai; Buchwald, Stephen L.
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7526 - 7537
