1: With ammonia; sodium in tetrahydrofuran T=-78°C; 0.416667 h; 2: With tert-butyl alcohol in tetrahydrofuran 0.0833333 h;

1.1: (S)-Corey-Bakshi-Shibata reagent; borane-THF / tetrahydrofuran; toluene / Cooling with ice; Inert atmosphere 2.1: bis(benzonitrile)palladium(II) dichloride / toluene / 1.75 h / Inert atmosphere; Reflux 3.1: ammonia; sodium / tetrahydrofuran / 0.42 h / -78 °C 3.2: 0.08 h View Scheme

1.1: bis(benzonitrile)palladium(II) dichloride / toluene / 1.75 h / Inert atmosphere; Reflux 2.1: ammonia; sodium / tetrahydrofuran / 0.42 h / -78 °C 2.2: 0.08 h View Scheme

pyridine; trichlorophosphate

T=195 - 200°C;