3-(4-丁氧基苯基)丙酸合成路线 （共 7 条）
反应条件
ethanol; nickel Hydrogenation;
参考文献
EMISPHERE TECHNOLOGIES, INC.
Patent: WO2008/112368 A2, 2008 ;
Location in patent: Page/Page column 33 ;
反应条件
potassium hydroxide 1.) MeOH, reflux, 8 h; 2.) H2O, reflux, 1.5 h; Multistep reaction;
参考文献
Freudenreich, Charles; Samama, Jean-Pierre; Biellmann, Jean-Francois
Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3344 - 3353
反应条件
1: HBr 2: (i) NaOMe, (ii) /BRN= 1102046/, (iii) aq. KOH View Scheme
参考文献
Mamalis,P. et al.
Journal of the Chemical Society, 1965 , p. 1829 - 1843
反应条件
(i) NaOMe, (ii) /BRN= 1102046/, (iii) aq. KOH; Multistep reaction;
参考文献
Mamalis,P. et al.
Journal of the Chemical Society, 1965 , p. 1829 - 1843
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Freudenreich, Charles; Samama, Jean-Pierre; Biellmann, Jean-Francois
Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3344 - 3353
反应条件
1: HCl / 1 h / Heating
2: hydrazin hydrate / 2 h / 100 °C
View Scheme
参考文献
Freudenreich, Charles; Samama, Jean-Pierre; Biellmann, Jean-Francois
Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3344 - 3353
反应条件
1: thionyl chloride / 1 h / Heating
2: toluene
View Scheme
参考文献
Freudenreich, Charles; Samama, Jean-Pierre; Biellmann, Jean-Francois
Journal of the American Chemical Society, 1984 , vol. 106, # 11 p. 3344 - 3353
